New secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora.
نویسندگان
چکیده
Three new secoiridoid glycosides, named picrogentiosides A (1), B (2) and C (3), have been isolated from the underground parts of Picrorhiza Scrophulariiflora, together with the two known compounds plantamajoside (4) and plantainoside D (5). Their structures were established by spectroscopic analyses and comparisons with data from related compounds. A pilot pharmacological study showed that picrogentiosides A (1) and B (2) have an immunomodulatory effect in vitro.
منابع مشابه
Three new caffeoyl glycosides from the roots of Picrorhiza scrophulariiflora.
From the underground parts of Picrorhiza scrophulariiflora, three new caffeoyl glycosides, scrocaffeside A-C (1-3), together with two caffeic acid derivates, 4-O-beta-D-glucopyranosyl caffeic acid (4) and 4-methoxy caffeic acid (5) and a phenylethanoid glycoside, scroside D (6), were isolated. Their structures were elucidated on the basis of chemical and spectroscopic evidence and comparisons w...
متن کاملChemical investigation of an antimalarial Chinese medicinal herb Picrorhiza scrophulariiflora.
An antimalarial medicinal plant Picrorhiza scrophulariiflora was chemically investigated as part of our ongoing research in traditional chinese medicines (TCM). Mass directed fractionation of the active part of the crude extract led to the isolation of ten main components, three new compounds (1-3) and seven known compounds (4-10). Compound 10 inhibited the growth of the Plasmodium falciparum 3...
متن کاملNeutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF-β Signaling.
Although acute lung injury (ALI) is a leading cause of death in intensive care unit, effective pharmacologic means to treat ALI patients are lacking. The rhizome of Picrorhiza scrophulariiflora used in a traditional herbal medicine in Asian countries has been shown to have anti-inflammatory function, and picroside II (PIC II) is known as a major constituent in the plant. Here, we examined wheth...
متن کاملKutkins- A Review of Chemistry and Pharmacology
Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste. In Ayurveda Picrorhiza kurroa is a reputed remedy for the treatment of liver diseases. The chemical composition of the Picrorhiza has been studied and active constituents are group of iridoid glycosides kno...
متن کاملEvaluation of Antidiabetic Activity of Picrorhiza Scrophulariiflora Pennell in High Fat Fed Diet with Streptozotocin Induced Type Ii Diabetic Rats
High energy-intake is a major factor revolved in type 2 diabetes. The objectives of this study is to set up a suitable animal model, which is similar to the human type 2 diabetes, 6 8 weeks old Sprague Dawley rats weighing 220 250 gm were consumed high fat diet (HFD) of 20% fat, 46% carbohydrate and 20% protein (w/w). Two weeks later the animals were given with intraperitonial injection of stre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 13 9 شماره
صفحات -
تاریخ انتشار 2008